Osteoarthritis Musculoskeletal Diseases
Conditions
Interventions
For the first research visit (up to 4 weeks pre-surgery) participants will receive two questionnaires through the post to complete and return upon their visit to Academic Rheumatology. These will take
Sponsors
University of Nottingham
Eligibility
Sex/Gender
All
Age
40 Years to 110 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients who attend Nottingham University Hospitals for total knee replacement surgery as treatment for osteoarthritis pain 2. Able to give informed consent 3. No prior history of knee surgery 4. Aged over 40 years (no upper age limit)
Exclusion criteria
Exclusion criteria: 1. Also have symptomatic hip OA pain 2. Diagnosed with major psychiatric or neurological illness 3. Have active cancer 4. Have sensory dysfunction 5. Have other pain conditions, e.g. fibromyalgia 6. Currently using strong opioid or neuropathic treatments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Pain is measured using the visual analogue score (VAS) and quantitative sensory testing (QST) at baseline and 6-months post-surgery 2. Levels of synovial inflammation measured using histopathology at baseline 3. sEH expression measured using nanobody assay at baseline 4. sEH activity measured using radiometric assay at baseline 5. Epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids (DHETs) measured using liquid chromatography-mass spectrometry at baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Contacts
Public ContactThomas Kurien
Outcome results
None listed