Radon Balneology and Physical Activity for Osteoporosis Prevention

Gastein Radon Balneology and Physical Activity for Osteoporosis Prevention: a randomized, placebo controlled intervention study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN09441803

Enrollment

Registered

2014-02-10

Start date

2010-09-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteporosis prevention Musculoskeletal Diseases Osteoporosis

Interventions

Exercise +/- Radon balneotherapy Study subjects are allocated by random into a ?radon group? and ?placebo group? Randomization will be computed in blocks of four with an equal treatment allocation ra

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Eligible participants are working females and males aged between 50 and 65. 2. Physical ability to meet the demands of the exercise program (i.e. at least 300 m of altitude difference per day) and sufficient knowledge of German to complete the questionnaires.

Exclusion criteria

Exclusion criteria: 1. Acute or chronic disturbances of the immune system 2. Hyperthyreosis 3. Cardiac arrhythmia 4. Renal insufficiency 5. Severe cardiovascular diseases 6. Acute infections or fever 7. Iritis 8. An acute attack of polyarthritis 9. Participants should not have used hormone replacement therapy or any other therapy affecting the bone metabolism during the last 12 months before enrollment.

Design outcomes

Primary

Measure	Time frame
Plasma levels of OPG for bone formation, RANKL for bone reabsorption and their ratio (OPG/RANKL) as a measure for the balance of bone metabolism Forearm venous blood is collected from all participants at baseline (day 0, timepoint 1; T1), end of first treatment week (day 6, timepoint 2; T2), start and end of the brush?up (day 60 and 63, timepoint 3; T3 and timepoint 4; T4) and 6 months after the last treatment (follow?up, day 240, timepoint 5; T5). Questionnaires assessing somatic complaints (Beschwerdenliste, Zerssen, D. v., 1976. Die Beschwerden- Liste - Manual. Weinheim: Beltz Test GmbH) and Quality of Life (Quality of life questionnaire of the European foundation for osteoporosis 41; QUALEFFO 41) are handed out for completion on T 1, T2, T3, T4, T5 and days T1, T3, T5, respectively.	—

Measure

Time frame

Plasma levels of OPG for bone formation, RANKL for bone reabsorption and their ratio (OPG/RANKL) as a measure for the balance of bone metabolism Forearm venous blood is collected from all participants at baseline (day 0, timepoint 1; T1), end of first treatment week (day 6, timepoint 2; T2), start and end of the brush?up (day 60 and 63, timepoint 3; T3 and timepoint 4; T4) and 6 months after the last treatment (follow?up, day 240, timepoint 5; T5). Questionnaires assessing somatic complaints (Beschwerdenliste, Zerssen, D. v., 1976. Die Beschwerden- Liste - Manual. Weinheim: Beltz Test GmbH) and Quality of Life (Quality of life questionnaire of the European foundation for osteoporosis 41; QUALEFFO 41) are handed out for completion on T 1, T2, T3, T4, T5 and days T1, T3, T5, respectively.

—

Secondary

Measure	Time frame
1. Plasma levels of Osteocalcin (OC), Osteopontin (OPN), Leptin, Parathyroid Hormone (PTH) and Adrenocorticotropic Hormone (ACTH) 2. Somatic complaints and self-reported health. Questionnaires assessing somatic complaints (Beschwerdenliste, Zerssen, D. v., 1976. Die Beschwerden- Liste - Manual. Weinheim: Beltz Test GmbH) and Quality of Life (Quality of life questionnaire of the European foundation for osteoporosis 41; QUALEFFO 41) are handed out for completion on T 1, T2, T3, T4, T5 and days T1, T3, T5, respectively.	—

Measure

Time frame

1. Plasma levels of Osteocalcin (OC), Osteopontin (OPN), Leptin, Parathyroid Hormone (PTH) and Adrenocorticotropic Hormone (ACTH) 2. Somatic complaints and self-reported health. Questionnaires assessing somatic complaints (Beschwerdenliste, Zerssen, D. v., 1976. Die Beschwerden- Liste - Manual. Weinheim: Beltz Test GmbH) and Quality of Life (Quality of life questionnaire of the European foundation for osteoporosis 41; QUALEFFO 41) are handed out for completion on T 1, T2, T3, T4, T5 and days T1, T3, T5, respectively.

—

Countries

Austria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026