Psychosis
Conditions
Interventions
The intervention is a 10-week personalized exercise programme in line with the volume of activity recommended by the NHS. We will work with participants to identify suitable exercise activities (.e.g.
Sponsors
University of Manchester (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Currently receiving help from an NHS Early Intervention Service 2. Experiencing certain psychological difficulties 3. Aged 18-35
Exclusion criteria
Exclusion criteria: 1. Aged below 18 or above 35 2. Pregnant 3. Experiencing a physical health condition which makes exercise a problem 4. Does not have sufficient English language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Acceptability and feasibility These will be assessed by analysing referral and recruitment rates, drop out rates and completion of assessment protocols. This includes assessment of number and proportion consenting to pre- and post-intervention physical and mental health assessments, fitness assessments, cognitive testing and brain scans, and numbers completing the exercise intervention. This will be assessed at the end of the study, by looking at consent and attrition rates (01/11/2014). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Positive and negative psychotic symptoms, depressed mood, anxiety, social functioning and quality of life will be assessed at baseline and at the end of the 10 week intervention. These will be assessed with the Postive and Negative Symptoms Scale (PANSS), the Beck Depression Inventory II (BDI-II), the Social Interaction Anxiety Scale (SIAS), the Social and Occupational Functioning Assessment Scale (SOFAS) the WHODAS (39) and the WHO Quality of Life 26 item version (WHOQoL Bref) respectively. 2. Cognitive function will be assessed at baseline and after the 10 week intervention. Participants will be seated at a laptop computer and will complete a series of computerised tasks. These tasks are very similar to the types of tests included in popular "brain training" packages available on the internet or on handheld gaming devices. In each task participants will be presented with stimuli (which will be either words, pictures, faces or shapes) and will be asked to make decisions about those stimuli. The different tests will assess a range of mental processes; for example, memory, planning and attention to information. 3. Change in brain structure relative to baseline: We will acquire structural images on the 3T Philips scanner at the Wellcome Trust CRF, using T1 weighted imaging sequences optimized for voxel based morphometry analysis. Individuals will be scanned before and after the intervention and we will use voxel based morphometry within SPM12 (statistical parametric mapping: www.fil.ion.ucl.ac.uk/spm) to explore grey matter changes. We will use a region of interest approach to explore changes in the hippocampus and temporal gyri. 4. Resting state brain connectivity: Functional imaging data will be acquired in the same scanning sessions as the structural data. Participants will be asked to rest with their eyes closed for 8.5 minutes. During this time, 256 images will be acquired using an echo-planar T2* imaging sequence. Images will be spatially pre-processed and t | — |
Countries
United Kingdom
Outcome results
None listed