Dengue (including Dengue Haemorrhagic Fever [DHF] and Dengue Shock Syndrome [DSS]) Infections and Infestations Dengue fever [classical dengue]
Conditions
Interventions
Insecticide-treated curtains deployed inside human habitations. The curtains are made from PermaNet® deltamethrin-coated polyester netting, a long-lasting impregnated material (Vestergaard-Frandsen, L
Bayer Environmental Science, Germany) designed to deliver a long-lasting formulation of the same insecticide.
Sponsors
Liverpool School of Tropical Medicine (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All occupied households 1.1. Persons aged 3 years or older with parental permission 1.2. Adults consenting to participate in the study living in the study area 1.3. Assent to participation for 8-17 year old persons
Exclusion criteria
Exclusion criteria: 1. Persons younger than 3 years old 2. Temporary visitors to the study areas 3. Adults who do not consent to participate 4. 8-17 year old persons who do not assent or who do not have parental permission to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of ITMs on dengue transmission - measured by detection of dengue specific antibodies in human blood, taken from householders within the study area, using the Plaque Reduction Neutralizing Antibody test (PRNT). PRNT is specific to dengue virus serotype, and is the gold standard against which all other dengue virus (DV) serological assays are validated. Blood samples will be collected from the study population at baseline and at three 9-month intervals thereafter (9, 18, 24 months post intervention) in householders that were not positive for all four circulating serotypes during the immediate preceding survey. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The effect of ITMs on household vector infestation and breeding ? primarily measured by: 1.1 The adult index (proportion of houses positive for adult Ae. aegypti) 1.2. The Breteau index (number of containers with immature vector stages/100 houses) Secondarily by the other Stegomyia indices: 1.3. Pupae per person index (number of pupae per number of people) 1.4. House index (percentage of houses found with immature stages of Ae. aegypti) 1.5. Container index (percentage of water-holding containers found with immature stages of Ae. aegypti). Six surveys will be conducted: Baseline and 1, 6, 12, 18 and 24 months post intervention. 2. Quantification of spill-over effects from treated clusters on nearby control clusters, a potential confounding effect on analyses as well as an indicator of potential community-level impact 3. Determining factors associated with adoption and continued use of ITMs, including the most effective diffusion mechanism (channel of communication) for ITM promotion, by household questionnaires and focus group discussions. Surveys will coincide with the serological surveys. | — |
Countries
England, Peru, United Kingdom
Outcome results
None listed