Prehospital Randomised Assessment of Mechanical compression Device In Cardiac arrest

Conditions

Out of hospital cardiac arrest Circulatory System Cardiac arrest

Keith Couper, Tom Quinn, Katie Booth, Ranjit Lall, Anne Devrell et al. (9 authors)

Resuscitation2020-10-0730 citations

10.1016/j.resuscitation.2020.09.033

Mechanical versus manual chest compressions in the treatment of in-hospital cardiac arrest patients in a non-shockable rhythm: a randomised controlled feasibility trial (COMPRESS-RCT).

Couper K, Quinn T, Lall R, Devrell A, Orriss B, Seers K, Yeung J, Perkins GD, COMPRESS-RCT collaborators.

2018-08-304 citations

10.1186/s13049-018-0538-6

Feasibility of data linkage in the PARAMEDIC trial: a cluster randomised trial of mechanical chest compression in out-of-hospital cardiac arrest

Chen Ji, Tom Quinn, Lucia Gavalova, Ranjit Lall, Charlotte Scomparin et al. (13 authors)

BMJ Open2018-07-0116 citations

10.1136/bmjopen-2018-021519

Post-admission outcomes of participants in the PARAMEDIC trial: A cluster randomised trial of mechanical or manual chest compressions.

Ji C, Lall R, Quinn T, Kaye C, Haywood K, Horton J, Gordon V, Deakin CD, Pocock H, Carson A, Smyth M, Rees N, Han K, Byers S, Brace-McDonnell S, Gates S, Perkins GD, PARAMEDIC trial Collaborators.

2017-07-0514 citations

10.1016/j.resuscitation.2017.06.026

Prehospital randomised assessment of a mechanical compression device in out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised trial and economic evaluation.

Gates S, Lall R, Quinn T, Deakin CD, Cooke MW, Horton J, Lamb SE, Slowther AM, Woollard M, Carson A, Smyth M, Wilson K, Parcell G, Rosser A, Whitfield R, Williams A, Jones R, Pocock H, Brock N, Black JJ, Wright J, Han K, Shaw G, Blair L, Marti J, Hulme C, McCabe C, Nikolova S, Ferreira Z, Perkins GD.

2017-03-0126 citations

10.3310/hta21110

Human factors in prehospital research: lessons from the PARAMEDIC trial

Helen Pocock, Charles D. Deakin, Tom Quinn, Gavin D. Perkins, Jessica Horton et al. (6 authors)

Emergency Medicine Journal2016-02-2517 citations

10.1136/emermed-2015-204916

Late-Breaking Clinical Trial Abstracts

Dayer, MD, Jones, S, Prendergast, B, Baddour, L, Lockhart, PB et al. (6 authors)

Circulation2014-12-0256 citations

10.1161/01.cir.0000457464.79076.2c

Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial.

Perkins GD, Lall R, Quinn T, Deakin CD, Cooke MW, Horton J, Lamb SE, Slowther AM, Woollard M, Carson A, Smyth M, Whitfield R, Williams A, Pocock H, Black JJ, Wright J, Han K, Gates S, PARAMEDIC trial collaborators.

2014-11-16303 citations

10.1016/s0140-6736(14)61886-9

Prehospital randomised assessment of a mechanical compression device in cardiac arrest (PaRAMeDIC) trial protocol.

Perkins GD, Woollard M, Cooke MW, Deakin C, Horton J, Lall R, Lamb SE, McCabe C, Quinn T, Slowther A, Gates S, PARAMEDIC trial collaborators.

2010-11-0535 citations

10.1186/1757-7241-18-58

Interventions

The unit of randomisation is the ambulance service vehicle (rapid response vehicles and ambulances). The intervention arm will receive resuscitation according to the Resuscitation Council (UK) 27 an

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients (both males and females) in cardiac arrest in the out of hospital environment 2. Resuscitation attempt is initiated by the attending paramedic, according to Joint Royal Colleges Ambulance Liaison Committee (JRCALC) guidelines 3. Patient is believed to be aged 18 years or over

Exclusion criteria

Exclusion criteria: 1. Traumatic cardiac arrest 2. Known or clinically apparent pregnancy

Design outcomes

Primary

Measure	Time frame
Survival to hospital discharge (the point at which the patient is discharged from the hospital acute care unit regardless of neurological status, outcome or destination).	—

Secondary

Measure	Time frame
1. Survived event (sustained return of spontaneous circulation [ROSC], with spontaneous circulation until admission and transfer of care to medical staff at the receiving hospital) 2. Survival to 12 months 3. Health related quality of life at 3 and 12 months (SF-12® Health Survey and Euroqol EQ-5D) 4. Neurological outcome at discharge from hospital, assessed by the Cerebral Performance Category (CPC) score 1-2 v 3-5 5. Neurological outcome at 12 months, assessed by the telephone version of Mini Mental State Examination (T3MS) 6. Anxiety and depression at 12 months, assessed by the Hospital Anxiety and Depression Scale (HADS) 7. Post-traumatic stress at 12 months, assessed by the post-traumatic stress disorder (PTSD) civilian checklist (PCL-C) 8. Hospital length of stay 9. Intensive care length of stay	—

Measure

Time frame

1. Survived event (sustained return of spontaneous circulation [ROSC], with spontaneous circulation until admission and transfer of care to medical staff at the receiving hospital) 2. Survival to 12 months 3. Health related quality of life at 3 and 12 months (SF-12® Health Survey and Euroqol EQ-5D) 4. Neurological outcome at discharge from hospital, assessed by the Cerebral Performance Category (CPC) score 1-2 v 3-5 5. Neurological outcome at 12 months, assessed by the telephone version of Mini Mental State Examination (T3MS) 6. Anxiety and depression at 12 months, assessed by the Hospital Anxiety and Depression Scale (HADS) 7. Post-traumatic stress at 12 months, assessed by the post-traumatic stress disorder (PTSD) civilian checklist (PCL-C) 8. Hospital length of stay 9. Intensive care length of stay

—

Countries

United Kingdom

Outcome results

None listed