A randomized, prospective, multicenter study of the effective treatments of panic disorder: cognitive behavioral therapy versus antidepressants versus combination therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN08156869

Enrollment

150

Registered

2006-07-19

Start date

2001-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Panic disorder Mental and Behavioural Disorders Panic disorder

Interventions

CBT: the CBT protocol is based on the work of Clark and Barlow. Patients in the CBT group received up to 21 CBT sessions each lasting approximately 50 minutes. From session 16 onwards, sessions were s

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients suffering from a primary diagnosis of panic disorder (PD) with or without agoraphobia (AG) (according to Diagnostic and Statistical Manual of mental disorders [DSM-IV] classification) recruited in 11 treatment facilities throughout the Netherlands between 1 April 2001 and 1 October 2003.

Exclusion criteria

Exclusion criteria: 1. Comorbid psychotic disorder 2. Drug dependence 3. Major affective disorder 4. Significant risk of suicidality 5. Pregnancy or lactation 6. Contraindications to either treatment modality

Design outcomes

Primary

Measure	Time frame
Short-term: 1. Hamilton anxiety 2. Hamilton depression 3. Frequency of panic attacks 4. Responder status 5. Symptom checklist-90 (SCL-90) 6. Fear questionnaire-subscale 7. Agoraphobia Long-term: 1. Remitter status 2. Panic coping 3. Quality of life 4. Hamilton anxiety 5. Hamilton depression	—

Secondary

Measure	Time frame
1. Treatment satisfaction 2. Locus of control 3. Fear of bodily sensations 4. Anticipation anxiety 5. Negative and positive self statements	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026