Informing fresh versus standard Issue red cell management

Conditions

Red blood cell transfusion Haematological Disorders Blood transfusion (without reported diagnosis)

Cook RJ, Heddle NM, Lee KA, Arnold DM, Crowther MA, Devereaux PJ, Ellis M, Figueroa P, Kurz A, Roxby D, Sessler DI, Sharon Y, Sobieraj-Teague M, Warkentin TE, Webert KE, Barty R, Liu Y, Eikelboom JW.

2017-10-0828 citations

10.1016/s2352-3026(17)30169-2

Effect of Short-Term vs. Long-Term Blood Storage on Mortality after Transfusion

Nancy M. Heddle, Richard J. Cook, Donald M. Arnold, Yang Liu, Rebecca Barty et al. (17 authors)

New England Journal of Medicine2016-10-24318 citations

10.1056/nejmoa1609014

Interventions

Patients requiring red blood cell transfusion will be randomized to one of the following conditions: 1. Freshest available red blood cells (experiment arm) 2. Standard-

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All adult patients (age >/= 18) will be included if: 1. Hospitalized at a participating centre (in-patient) 2. Undergoing a red cell transfusion

Exclusion criteria

Exclusion criteria: 1. Specific requirement for fresh blood (e.g., sickle cell disease, transfuion-dependent thalassemia, fresh cells ordered by care provider) 2. Pre-planned directed or autologous donation 3. Request for un-crossmatched blood 4. Anticipated massive transfusion as communicated from clinical area

Design outcomes

Primary

Measure	Time frame
In-hospital mortality	—

Secondary

Measure	Time frame
Time to event (death)	—

Countries

Australia, Canada, Israel, United States of America

Outcome results

None listed