Keratoconus Eye Diseases Keratoconus
Conditions
Interventions
Randomized, bilateral-controlled, prospective clinical investigation (one eye acts as control while opposite acts as study) whereby riboflavin eye drops are applied and ultraviolet A light is shone in
Sponsors
Record Provided by the NHSTCT Register - 2007 Update - Department of Health
Eligibility
Inclusion criteria
Inclusion criteria: 36 patients with moderate bilateral keratoconus recruited from the corneal and contact lens clinics at Guy's and St. Thomas' NHS Foundation Trust. Inclusion criteria: 1. Age 18 to 70 2. Must fully understand the investigative nature of the study 3. Moderate to advanced bilateral keratoconus 4. No known allergies to pre- and post-operative medications Willingness to attend for follow-up examinations
Exclusion criteria
Exclusion criteria: 1. Age below 18 2. Other pre-existing ophthalmic pathology 3. Previous ophthalmic surgery 4. Unilateral keratoconus 5. Severe keratoconus in which the cornea is so distorted that accurate refractive and corneal measurements cannot be obtained (in these eyes data confirming stability or progression is not possible)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine whether Riboflavin/ UVA corneal cross-linkage can prevent the progression of keratoconus. The non-treated eye will act as a control. | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine whether Riboflavin/UVA corneal cross-linkage can reverse some of the bowing of the cornea caused by keratoconus. To determine whether non-treated eyes have progression of keratoconus compared to those eyes which underwent cross-linkage treatment. | — |
Countries
United Kingdom
Outcome results
None listed