The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS project): a randomised controlled trial comparing the effects of differing therapeutic agents for detoxification from either street heroin or methadone

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN07752728

Enrollment

120

Registered

2002-05-29

Start date

2002-03-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Participants are taking street opiates or street methadone Mental and Behavioural Disorders Drug dependence

Interventions

A randomised controlled trial will be implemented using buprenorphine sublingual tablets or dihydrocodenine. Prescriptions for either of the two therapeutic agents will be randomly assigned to partici

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Above the age of 18 years 2. Using moderate levels of street opiates or taking street methadone 3. Have expressed a wish to detoxify from either street heroin or methadone through a standard monitored process 4. Participants must be registered at one of the practices taking part in the LEEDS project

Exclusion criteria

Exclusion criteria: Does not comply with above inclusion criteria

Design outcomes

Primary

Measure	Time frame
Abstinence from street opiates at receiving the final prescription, indicated by a urine test free of illicit opiates or their metabolites.	—

Secondary

Measure	Time frame
1. Significant adverse effects 2. Inappropriate use of prescribed medication (e.g. intentional overdose) 3. Presentation at Accident and Emergency Departments 4. Admission to hospital	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 3, 2026