Intervention versus conservative treatment strategy in patients with unstable angina or non-ST elevation myocardial infarction (the Third Randomised Intervention Treatment of Angina trials [RITA 3])

Conditions

Unstable angina/non-ST elevation myocardial infarction Circulatory System Infarction

Henderson RA, Jarvis C, Clayton T, Pocock SJ, Fox KA.

2015-08-0136 citations

10.1016/j.jacc.2015.05.051

Timing of angiography with a routine invasive strategy and long-term outcomes in non-ST-segment elevation acute coronary syndrome: a collaborative analysis of individual patient data from the FRISC II (Fragmin and Fast Revascularization During Instability in Coronary Artery Disease), ICTUS (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes), and RITA-3 (Intervention Versus Conservative Treatment Strategy in Patients With Unstable Angina or Non-ST Elevation Myocardial Infarction) Trials.

Damman P, van Geloven N, Wallentin L, Lagerqvist B, Fox KA, Clayton T, Pocock SJ, Hirsch A, Windhausen F, Tijssen JG, de Winter RJ.

2012-02-0120 citations

10.1016/j.jcin.2011.10.016

Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials.

Damman P, Clayton T, Wallentin L, Lagerqvist B, Fox KA, Hirsch A, Windhausen F, Swahn E, Pocock SJ, Tijssen JG, de Winter RJ.

2011-09-19100 citations

10.1136/heartjnl-2011-300453

5-year outcome of an interventional strategy in non-ST-elevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial.

Fox KA, Poole-Wilson P, Clayton TC, Henderson RA, Shaw TR, Wheatley DJ, Knight R, Pocock SJ.

2005-09-01236 citations

10.1016/s0140-6736(05)67222-4

Interventions

Angiography followed by Percutaneous Coronary Intervention (PCI) or Coronary Artery Bypass Grafting (CABG) versus conservative management.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients within 24 hours of an index episode of ischaemic pain at rest or patients will have documented evidence of coronary disease with at least one of: 1. Electrocardiogram (ECG) evidence of myocardial ischaemia 2. Pathological Q waves on an ECG suggesting previous myocardial infarction 3. Arteriographically proven coronary disease on a previous angiogram

Exclusion criteria

Exclusion criteria: All those with probable evolving myocardial infarction, including those for whom reperfusion therapy was indicated, were ineligible. Those in A1 whom new pathological Q waves developed, or those with creatine kinase or creatine kinase Myocardial Bands (MB) concentrations twice the upper limit of normal before randomisation, were excluded. Also excluded were those with myocardial infarction within the previous month, Percutaneous Coronary Intervention (PCI) in the preceding 12 months, or Coronary Artery Bypass Grafting (CABG) at any time.

Design outcomes

Primary

Measure	Time frame
The co-primary endpoints were a combined rate of death, non-fatal myocardial infarction, or refractory angina at 4 months; and a combined rate of death or non-fatal myocardial infarction at 1 year. Analysis was by intention to treat.	—

Secondary

Measure	Time frame
Secondary outcomes included subsequent revascularisation, angina scores, anti-anginal medication, quality-of-life scores, and health-economic evaluations.	—

Countries

United Kingdom

Outcome results

None listed