Impaired glucose tolerance/ renal changes in prediabetes Nutritional, Metabolic, Endocrine Impaired glucose tolerance/ renal changes in prediabetes
Conditions
Interventions
12 participants were recruited in each of the two groups. Statistical calculation was carried out by the Institute of Statistics, Technical University of Munich.
Participants of both groups (control
Sponsors
Technical University of Munich (Germany)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Males 2. 18-70 years old 3. Impaired Glucose Tolerance (for the intervention group [IGT-Group]) (tested by the oral glucose tolerance test according to the World Health Organisation) and normoglycemic patients (for control group [healthy subjects])
Exclusion criteria
Exclusion criteria: 1. Renal or liver insufficiency 2. Micro-or macro-albuminuria 3. Overt diabetes mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The following were measured at rest (U1 rest, U2 rest) and during hyperglycemic stress testing (U1 stress, U2 stress) with and without AT1 receptor blocker treatment: 1. Glomerular filtration rate (inulin clearance) 2. Renal plasma flow (Para-AminoHippurate [PAH] clearance) U1: Without AT1 receptor blocker U2: After a 4-week treatment with valsartan | — |
Secondary
| Measure | Time frame |
|---|---|
| The following were assessed at U1 and U2: 1. High-sensitivity C-Reactive Protein (CRP) 2. Adiponectin 3. HbA1c (blood tests) U1: Without AT1 receptor blocker U2: After a 4-week treatment with valsartan | — |
Countries
Germany
Outcome results
None listed