Critically ill medical and surgical patients Not Applicable Intensive care unit
Conditions
Interventions
This is a randomised controlled trial. Patients will be randomly assigned to receive intensive insulin therapy (maintenance of blood glucose at a level between 4.4 - 6.1 mM/l or 80 - 110 mg/dl) or con
Sponsors
King Fahad National Guard Hospital (Saudi Arabia)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults (greater than 18 years old) able to give consent (directly or via proxy) 2. Random admission blood glucose level greater than 6.1 mM/l (greater than 110 mg/dl)
Exclusion criteria
Exclusion criteria: 1. Type I diabetes 2. Patients admitted with diabetic ketoacidosis 3. Patients with terminal illness (survival judged by the treating physician less than four weeks) 4. Patients with do not resuscitate (DNR) orders 5. Pregnancy 6. Patients with expected intensive care unit (ICU) length of stay (LOS) of less than 24 hours 7. History of hypoglycaemia during the same hospitalisation 8. Seizure disorder (known active in the last 6 months) 9. Post-cardiac arrest patients 10. Readmission to ICU within the same hospitalisation 11. Brain death 12. Liver transplant 13. Enrolled in another competing study 14. Refused consent 15. No consent within 24 hours of meeting inclusion criteria 16. Other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All cause mortality in the ICU | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hospital outcome 2. Cause of death 3. ICU and hospital LOS 4. Mechanical ventilation duration 5. The need for renal replacement therapy 6. Transfusion requirements 7. ICU acquired infections 8. Causes of death | — |
Countries
Saudi Arabia
Outcome results
None listed