Do positive end-expiratory pressure-induced changes in cardiac output indicate fluid responsiveness in anaesthetised patients?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN07173607

Enrollment

Registered

2007-02-14

Start date

2007-01-08

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthetised patients Surgery

Interventions

While monitoring cardiac Stroke Volume (SV) we alternate the Positive End-Expiratory Pressure (PEEP) by 10 cm H2O. If the PEEP-alteration results in a change in SV of more than 5 mL we hypothesise tha

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients admitted to Aalborg Hospital for elective surgery of the spinal column.

Exclusion criteria

Exclusion criteria: 1. Severe right-sided cardiac insufficiency 2. Severe anaemia 3. Pregnancy 4. Children (age less than 18 years) 5. Patients without esophageal doppler monitoring of cardiac output 6. Patients who experience severe complications during anaesthesia

Design outcomes

Primary

Measure	Time frame
Coherence between the magnitude of the PEEP-induced alterations of SV and the patients fluid responsiveness.	—

Secondary

Measure	Time frame
1. Coherence between the magnitude of PEEP-induced alterations of pulse pressure and the patients fluid responsiveness 2. Coherence between the magnitude of PEEP-induced alterations of heart rate and the patients fluid responsiveness	—

Countries

Denmark

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026