Asthma Respiratory Asthma
Conditions
Interventions
All patients will complete a questionnaire about:
1. History of deep venous thrombosis (DVT) and pulmonary embolism (PE)
2. History of asthma
3. Medication use
The results of all included patients wi
5(4):692-9). Because sex and age have a large influence on the incidence of DVT and pulmonary embolism (PE), the reference general population will be matched to sex and age for all patients. The study
Sponsors
Astmafonds (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-88 years old 2. Patients recruited from outpatient clinics from the Academic Medical Centre Amsterdam, Medical Center Leeuwarden and the Dutch High Altitude Asthma Clinic, Davos, Switzerland 3. Confirmed diagnosis of asthma according to Global Initiative for Asthma (GINA) 2010 guidelines 4. Diagnosis of severe asthma according to the international consensus 2009 (IMI-UBIOPRED)
Exclusion criteria
Exclusion criteria: 1. Severe co-morbidities that could interfere with coagulation (Including cancer, other severe inflammatory diseases and human immunodeficiency virus (HIV) 2. Severe psychiatric illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative number of first DVT and PE events during lifetime as compared to the sum of the expected cumulative hazards of first DVT and PE events from all patients in an age- and sex-matched general population | — |
Secondary
| Measure | Time frame |
|---|---|
| Hazard ratio for PE and DVT of of asthma associated factors (like oral and inhalational corticosteroids, atopy, duration of asthma, age of onset) | — |
Countries
Netherlands
Outcome results
None listed