Concentration of polyphenols in urine and their kinetics in plasma Not Applicable
Conditions
Interventions
Intervention 1: 100 ml of light soda water and 400 ml of water
Intervention 2: 100 ml of grape extract, 100 ml of light soda water and 300 ml of water
Intervention 3: 2
Sponsors
Ministry of Economy and Competitiveness ? INNPRONTA (Miguel Torres S.A) (Spain)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy adults (females and males), aged 20-40 years
Exclusion criteria
Exclusion criteria: 1. Previous history of cardiovascular disease (ischemic heart disease - angina or recent or old myocardial infarction, cerebral vascular accident, or peripheral vascular disease) 2. Homeostatic disorders 3. Any several chronic diseases 4. Hypertension or dyslipidemia 5. Grape intolerance or allergic 6. Smoking subjects 7. Alcoholism 8. Other toxic abuse
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Before (0 hours) and after each intervention (6 hours) the following measures were taken: 1. Blood pressure 2. Body weight 3. Waist perimeter 4. Glucose 5. Lipid profile 6. Biomarkers of oxidative stress and systematic inflammation 7. Coagulation factor and vitamin levels | — |
Primary
| Measure | Time frame |
|---|---|
| Polyphenols will be identified through liquid chromatography coupled to Orbitrap mass spectrometry. Concentrations of polyphenols will be quantified by liquid chromatography coupled to tandem mass spectrometry (LC?MS/MS). Polyphenols will be quantified at 0 to 24 hours of each intervention. | — |
Countries
Spain
Outcome results
None listed