Study to determine the influence of incision position on physiological and biochemical changes in tissue skin flaps after surgery for total knee replacement.

Study to determine the influence of incision position on physiological and biochemical changes in tissue skin flaps after surgery for total knee replacement: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN06592799

Enrollment

Registered

2014-10-07

Start date

2011-05-10

Completion date

Unknown

Last updated

2017-07-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis Musculoskeletal Diseases

Interventions

Patients are allocated to treatment via an online randomisation system provided by www.sealedenvelopes.com. Patients either received a midline incision or medial parapatellar incision. All other aspe

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who require total knee replacement 2. Sex - Male or Female subjects 3. Age ? Minimum age of 18, no upper age limit 4. Subjects, who in the opinion of the Investigator are able to understand this investigation, co operate with the investigation procedures 5. Subjects who are able to give voluntary, written informed consent to participate in this investigation and from whom consent has been obtained

Exclusion criteria

Exclusion criteria: 1. Patients who require revision knee surgery 2. Patients who have had previous surgery or trauma to the knee that may influence the blood supply to the skin covering the knee 3. Patients who are clinically obese 4. Patients who have vascular disease 5. Subjects who are currently involved in any injury litigation claims

Design outcomes

Primary

Measure	Time frame
1. To determine the influence of incision position for total knee replacement on cutaneous blood flow This measure at baseline (pre-operatively) and then at 24 hours (Day 1) and 72 hours (Day 3) post-operatively. Blood flow was measured using Laser Speckle Contrast Blood Perfusion Imager, Moor FLPI (Moor Instruments, Axminster, UK).	—

Secondary

Measure	Time frame
1. To determine the influence of incision position for total knee replacement on metabolic accumulations in the interstitial fluid of the resultant skin flap 2. To determine the effects of incision position on nerve innervation of the overlying skin flap during total knee replacement and patient perception of post operative pain 3. To determine rates of early sites specific infection for both midline and medial parapatellar incisions	—

Measure

Time frame

1. To determine the influence of incision position for total knee replacement on metabolic accumulations in the interstitial fluid of the resultant skin flap 2. To determine the effects of incision position on nerve innervation of the overlying skin flap during total knee replacement and patient perception of post operative pain 3. To determine rates of early sites specific infection for both midline and medial parapatellar incisions

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 5, 2026