Anaemia Haematological Disorders Other anaemias
Conditions
Interventions
Stable patients requiring blood transfusions for anaemia more often than every 6 weeks will be recruited. They will be randomised to receive two transfusions of four units of "fresh" blood (less than
Sponsors
Record provided by the NHS Trusts Clinical Trials Register - Department of Health (UK)
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients 18 and over with a haematological disorder requiring regular red cell transfusion (eg myelodysplastic syndrome, aplastic anaemia, etc) 2. Able to give informed consent 3. Serum creatinine <200 umol/l within past 2 months
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 48-hour post transfusion haemoglobin (Hb) increment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in red cell 2,3-DPG concentration and Hb-oxygen affinity (P50) 2. Subsequent changes in Hb at 14 days and before next transfusion 3. Changes in patients' quality of life (QOL) as measured by SF-36 health survey and a visual analogue scale | — |
Countries
United Kingdom
Outcome results
None listed