Genetics of aspirin resistance

An investigation into the genes underlying the clinical syndrome of aspirin resistance: a non-randomised interventional treatment trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN06023644

Enrollment

100

Registered

2010-04-23

Start date

2007-01-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Cardiovascular

Interventions

As of 01/08/2016: Subjects will attend clinic following an overnight fast, and having abstained from tobacco, caffeine-containing drinks and alcohol for at least 12 hours. 100 ml blood will be taken f

Eligibility

Inclusion criteria

Inclusion criteria: Male or female aged 18 or more

Exclusion criteria

Exclusion criteria: 1. Significant co-morbidity 2. Current regular therapy with any drug 3. Ingestion of aspirin, other non-steroidal anti-inflammatory drug, or other anti-platelet agent within the previous 30 days 4. Previous reaction to aspirin or other anti-platelet drug 5. History of dyspepsia or peptic ulceration 6. Pregnancy or female currently trying to conceive. Females of reproductive age wishing to take part will be asked to undergo a pregnancy test prior to inclusion, and will participate only if the test is negative.

Design outcomes

Primary

Measure	Time frame
Presence of aspirin resistance at 1 month	—

Secondary

Measure	Time frame
Presence/absence of genetic polymorphisms in a number of candidate genes possibly related to aspirin at 1 month	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026