Safety and efficacy study of high cut-off haemodialysis as a maintenance therapy for end stage renal failure

Safety and efficacy study of high cut-off haemodialysis as a maintenance therapy for end stage renal failure: a randomised crossover trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN06015076

Enrollment

Registered

2010-10-14

Start date

2010-07-25

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End stage renal failure, haemodialysis Urological and Genital Diseases Chronic renal failure

Interventions

High cut-off dialysis

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Functioning AV-fistula 2. Between the ages of 18 and 80 years 3. End Stage Renal Failure (ESRF) undergoing regular haemodialysis (for > 3 months)

Exclusion criteria

Exclusion criteria: 1. Terminal illness 2. Dialysis catheter in-situ 3. History of recurrent/poorly controlled infections 4. Inflammatory disease 5. Immunosuppressants 6. Cardiac or respiratory failure

Design outcomes

Primary

Measure	Time frame
Safety as defined by the maintenance of serum albumin.	—

Secondary

Measure	Time frame
1. Kinetics of removal of uraemic toxins (middle molecules and protein bound toxins) and the corresponding sustained reductions seen with the different dialysis schedules evaluated. 2. Dialysis dose 3. Quality of life 4. Thrombosis 5. Pulse wave velocity	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026