Neonatal respiratory failure (respiratory distress syndrome) Neonatal Diseases Respiratory failure
Conditions
Interventions
Patients were randomised at four hours of age to receive either standard neonatal intensive care, or standard care plus continuous negative extrathoracic pressure (CNEP, -4 to -6 cm H2O) applied withi
Sponsors
University Hospital of North Staffordshire (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The trial was undertaken in two neonatal intensive care units, Queen Charlotte's and Chelsea Hospital (QCCH) and North Staffordshire Maternity Hospital (NSMH), between October 1989 and November 1993. There were 244 patients: birth weight 1.53 ± 0.69 kg (mean ± SD), gestational age 30.4 ± 3.5 weeks, with respiratory failure. Patients were considered for entry at 2 hours of age if they required additional inspired oxygen or ventilation to maintain an arterial partial pressure of oxygen (PO2) of =8 kPa (60 mm Hg: conversion factor 7.5) or an arterial partial pressure of carbon dioxide (PCO2) of <6.5 kPa at Queen Charlotte's and Chelsea Hospital (QCCH) or 8 kPa at North Staffordshire Maternity Hospital (NSMH). This latter difference was because the two participating units had different practices at the time the trial commenced. Patients were randomised if, after a second assessment at 4 hours of age, they required =40% inspired oxygen or ventilation to maintain these blood gas measurements.
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed