Invasive Pneumococcal Disease Infections and Infestations Streptococcal infection, unspecified site
Conditions
Interventions
Participating General Practitioners (GP) in Hertfordshire and Gloucestershire in the UK will identify potential participants and provide parents/legal guardians with an information pack about the stud
Sponsors
Health Protection Agency (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. At least one child aged 1 to 5 years in the household 2. Written informed consent obtained for the child's parent/legal guardian and participating household contacts
Exclusion criteria
Exclusion criteria: 1. Moderate to severe cerebral palsy or other debilitating condition 2. Syndromes and neurological disorders affecting swallowing 3. Ear, nose & throat disorders affecting local anatomy for swabbing (e.g. malformed ears) 4. Confirmed or suspected immunodeficiency (congenital or acquired) or on immunosuppressive therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Pneumococcal carriage rates for PCV13 and non-PCV13 serotypes in children aged 20 years) two years after the introduction of PCV13 3. Invasiveness of any emerging replacement carriage serotypes by estimating case: carrier ratio (CCR) using national surveillance data for invasive pneumococcal disease | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Carriage rates of individual serotypes 2. Compare carriage by PCV7/PCV13 vaccination status in vaccine eligible cohorts 3. Compare, by age-group, changes in carriage serotypes with previous carriage studies performed by the HPA in 2001/02 and 2008/09 in children and adults | — |
Countries
United Kingdom
Outcome results
None listed