Chronic respiratory disease Respiratory Other chronic obstructive pulmonary disease
Conditions
Interventions
Treatment for patients in the intervention group will start within 48 hours of admission for an acute exacerbation of chronic respiratory disease. It will take the form of a daily, individually prescr
Sponsors
University Hospitals of Leicester NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged 40 and over of either sex who are admitted to hospital with an acute exacerbation of chronic respiratory disease 2. Ability to give informed consent
Exclusion criteria
Exclusion criteria: 1. Musculoskeletal or neuromuscular conditions that significantly contribute to exercise limitation 2. Psychiatric or neurological conditions that render the patient unable to comply with the rehabilitation programme 3. Not living independently at the time of admission 4. Admission for an acute myocardial infarction 5. Terminal disease with an estimated survival time of less than three months 6. Four or more hospitalisations for acute exacerbations of chronic respiratory disease in the preceding 12 month period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital readmission rate at 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Exercise capacity, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 2. Health status, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 3. Psychological wellbeing, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 4. Muscle strength and thickness, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 5. Biomarkers, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 6. Spirometry, measured at discharge home, 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 7. Length of stay, measured at discharge home 8. Nutritional status, measured at 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 9. Muscle structure changes, measured at 6 weeks after randomisation, 6 months after discharge and 12 months after discharge 10. Focus groups for psychological analysis, measured at 12 months after discharge 11. Healthcare utilisation, measured at 12 months after discharge | — |
Countries
United Kingdom
Outcome results
None listed