Cardiac atrial fibrillation Circulatory System Cardiac atrial fibrillation
Conditions
Interventions
Biopsies of right atrial appendages in patients in SR, with paroxysmal and persistent AF and undergoing for open chest surgery.
Sponsors
Maastricht University (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients applying to the predefined groups 2. Patients have given written consent 3. Both women and men between 18 years (included) and 70 years (included) old
Exclusion criteria
Exclusion criteria: 1. Patients who are scheduled for re-operation 2. Patients who do not speak/understand Dutch 3. Patients with sick sinus syndrome, atrioventricular (AV)-block or internal pacemaker 4. Patients who are not will-competent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured on day of biopsy: 1. To study the intracellular calcium alterations in human paroxysmal and persistent AF and the proarrhythmic effects of these alterations in comparison to SR 2. To study the nuclear calcium signaling in human paroxysmal and persistent AF in comparison to SR 3. To determine the Ca2+-dependent transcription pathways activated in AF and to study the consequences of the inactivation of these pathways on atrial cell electrical properties (i.e. AP, currents) and function (contraction) | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured on day of biopsy: 1. To determine the type of intracellular Ca2+ signals which can trigger cellular arrhythmias 2. To determine the key elements which play a major role in the activated calcium-dependent transcription pathways for drug targets 3. Long term goals: to restore contraction in AF and to prevent thrombosis | — |
Countries
Netherlands
Outcome results
None listed