Carbon monoxide poisoning Injury, Occupational Diseases, Poisoning Accidental poisoning by and exposure to other gases and vapours
Conditions
Interventions
Intervention: Non-invasive CPAP ventilation using a tight mask and standard respirator equipment
Control: Oxygen inhalation therapy by a simple facemask with oxygen reservoir
Sponsors
Medical University of Vienna
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients (i.e. at least 18 years old) treated at the Emergency Department 2. Elevated levels of COHb (COHb >= 7%) AND either assured CO-exposition (for example, faulty gas-heater, fire) or symptoms consistent with CO poisoning
Exclusion criteria
Exclusion criteria: 1. Patients being comatose on admission 2. Patients intubated by Emergency Medical Service 3. Patients requiring mechanical ventilation 4. Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absence of neuropsychological sequelae 1 month after intoxication | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time until COHb-level reaches 3% or less 2. Changes in neuropsychological sequelae between hospital discharge and 1 month after intoxication 3. Quality of life after 1 month 4. Mortality after 1 month 5. Adverse events 6. Length of Stay at ICU 7. Length of stay in hospital 8. Hospital admission within 1 month | — |
Countries
Austria
Outcome results
None listed