Infectious exacerbations of COPD and hypercapnic encephalopathy Respiratory
Conditions
Interventions
11 patients with infectious exacerbations of COPD and hypercapnic encephalopathy with GCS < 10 were designated to receive BiPAP S/T with AVAPS.
The control group was then selected from patients in t
Sponsors
San Francisco de Quito University (Universidad San Francisco de Quito) (Ecuador)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age > 40 years 2. COPD was diagnosed on the basis of the recommendations of the American Thoracic Society 3. Hypercapnic encephalopathy with GCS < 10 were designated to receive BiPAP S/T with AVAPS 4. The control group was then selected from patients in the emergency unit with infectious exacerbations of COPD and encephalopathy (GCS < 10). Patients were treated immediately and referred to us by doctors who were unaware of the study. Each patient was treated with NIV and was selected according to: Acute Physiology and Chronic Health Evaluation II (APACHE II) score within 4 points, age within 10 points, pH within 0.04, GCS within 2 points, and BMI within 2 points 5. Informed consent
Exclusion criteria
Exclusion criteria: 1. A face deformity 2. Obstruction of the upper respiratory tract owing to recent surgery or trauma 3. Alterations in the central nervous system not related to a hypercapnic encephalopathy 4. Cardiogenic pulmonary edema, pneumothorax, pulmonary thromboembolism, hemoptysis, or septic shock 5. Urgent intubation owing to cardiac and/or respiratory arrest, and hemodynamic instability with a systolic arterial blood pressure (BP) of less than 80mmH 6. Other neurological illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of consciousness (Glasgow Coma Scale score) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of mechanical ventilation 2. Hospital stay, and 3. Progression (exhaled tidal volume, inspiratory pressure, and arterial blood gases) | — |
Countries
Ecuador
Outcome results
None listed