Nutritional, Metabolic, Endocrine: Metabolic syndrome Nutritional, Metabolic, Endocrine Metabolic syndrome
Conditions
Interventions
Comparison of three dietary approaches
Sponsors
Record Provided by the NHSTCT Register - 2006 Update - Department of Health (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Males or non-pregnant females fulfilling the criteria for the metabolic syndrome - these include the presence of three or more of the following: 1. Abdominal obesity (waist circumference >102 cm in men and >88 cm in women) 2. Triglyceride level >150 mg/dl 3. HDL cholesterol 130 mm systolic or 85 mm diastolic 5. Fasting plasma glucose >6.1 mmol/dl
Exclusion criteria
Exclusion criteria: 1. Recent cardiovascular event, i.e. stroke, myocardial infarction or pulmonary embolism, within past 4 months 2. Ongoing chronic inflammatory condition: vasculitis, ulcers, inflammatory bowel disease, malignant disorder 3. Renal impairment (creatinine >135) 4. Hepatic impairment (ALT or AST> 4x upper limit of normal) 5. On statin therapy for dyslipaemia 6. Poorly controlled diabetes. Type 2 diabetes on insulin therapy. Type 2 diabetes on thiazolidinione 7. Untreated thyroid disorders - should be stable on thyroid medication for at least 3 months 8. Known Cushing's syndrome 9. On an anorectic agent, i.e., Orlistat, sibutramine - can be given a 4-week washout period 10. Food allergies/intolerance 11. Vegetarian
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improving the cardiovascular risks associated with the metabolic syndrome has long-term beneficial effects on health and quality of life. Management through dietary lifestyle changes is possibly the healthier option with less chances of side effects or interactions as would be expected through drugs. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed