Intracranial haemorrhage in patients with haematological malignancies Haematological Disorders Intracranial haemorrhage
Conditions
Interventions
Case-control study with prospective active surveillance of cases
Sponsors
National Health Service Blood and Transplant (NHSBT) (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All thrombocytopenic adult haematology patients in the UK undergoing intensive chemotherapy (defined as chemotherapy expected to cause a significant thrombocytopenia 5 days) or a stem cell transplant who had an intracranial haemorrhage within the study period 2. Aged 16 years or older 3. Only patients being treated with curative intent 4. All severities of intracranial haemorrhage 5. All types of intracranial haemorrhage
Exclusion criteria
Exclusion criteria: Does not meet the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Factors (e.g., age, type of haematological disease, treatment, infection) associated with an increased risk of developing an intracranial haemorrhage | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of intracranial haemorrhage in thrombocytopenic haematology patients 2. Short-term outcomes for these patients (e.g., death or persistent neurological deficit) 3. Rates of death 4. Rates of significant neurological deficits | — |
Countries
United Kingdom
Outcome results
None listed