Hyperglycaemia in critically ill patients Nutritional, Metabolic, Endocrine Hyperglycaemia
Conditions
Interventions
The total projected recruitment for this trial is 6000 patients: 4000 in Australia and New Zealand (between April 2005 and December 2006) and 2000 in Canada (between May 2006 and September 2009). The
Sponsors
Australian and New Zealand Intensive Care Society (Australia)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients (18 years or over, either sex) that are expected to require treatment in the ICU that extends beyond the calendar day following the day of admission 2. Patient has an arterial line in place or placement of an arterial line is imminent (within the next hour) as part of routine ICU management
Exclusion criteria
Exclusion criteria: Patients are excluded from the study if ONE or MORE of the following criteria are present: 1. Age less than 18 years 2. Imminent death and the treating clinicians are not committed to full supportive care 3. Patients admitted to the ICU for treatment of diabetic ketoacidosis or hyperosmolar state 4. Patients that are expected to be eating before the end of the day following admission 5. Patients who have suffered hypoglycaemia without documented full neurological recovery 6. Patients thought to be at abnormally high risk of suffering hypoglycaemia 7. If a patient has previously been enrolled in the study 8. If the patient cannot provide prior informed consent, there is documented evidence that the patient has no legal surrogate decision maker and it appears unlikely that the patient will regain consciousness or sufficient ability to provide delayed informed consent 9. The patient has been in the study ICU or another ICU for longer than 24 hours for this admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 90 day all-cause mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| Determined over the same period (90 days): 1. Death in intensive care unit by day 28 and by 90 days 2. Length of intensive care unit stay 3. Length of hospital stay 4. The need for organ support (intropes, renal replacement therapy and positive pressure ventilation) 5. Incidence of blood stream infections 6. Incidence and severity of hypoglycaemia Also in a subgroup of patients admitted with a diagnosis of traumatic brain injury, a follow up to determine long term functional status as determined by Extended Glasgow Outcome Scores (GOSE) will be collected at day 90 and six months. | — |
Countries
Australia, Canada, New Zealand
Outcome results
None listed