Influence of the polymorphism of the serotonin transporter promoter gene on effects of selective serotonin re-uptake inhibitors (SSRIs) in experimental panic provocation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN04559282

Enrollment

Registered

2005-09-16

Start date

2005-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental and behavioural disorders Mental and Behavioural Disorders

Interventions

Treatment with SSRI versus placebo for eight weeks (double-blind, randomized, within-subjects cross-over), CCK-4 challenge on respective days 42

Eligibility

Inclusion criteria

Inclusion criteria: Healthy volunteers (age 18-40 years)

Exclusion criteria

Exclusion criteria: 1. Current and life-time psychiatric disorders 2. Medical or neurological illnesses 3. Shift work 4. Transcontinental flights during the past four weeks

Design outcomes

Primary

Measure	Time frame
PANAS under basal conditions and IDCL for panic items and 100 mm VAS for 'anxiety' and 'tension' after CCK-4 challenge	—

Secondary

Measure	Time frame
Other psychometric, neuropsychological, autonomous, psychophysiological and neuroendocrine parameters	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026