A double-blind, placebo-controlled parallel-group pilot study of the effectiveness of D-cycloserine in reducing craving during cue-exposure therapy in abstinent alcohol-dependant subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN04481866

Enrollment

Registered

2006-09-29

Start date

2005-12-19

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental and Behavioural Disorders: Alcohol dependence Mental and Behavioural Disorders Alcohol dependence

Interventions

RCT: [A] D-cycloserine

[B] placebo. Screening visit: medical and psychiatric history, physical exam, biochemistry and haematology, liver function, drugs of abuse screen and ECG. Personality Questionnaire - TPQ and EPQ, Se

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 24 abstinent alcohol dependant males who attend the Bristol Area Specialist Alcohol Service. 12 in each group, D-cycloserine and placebo

Exclusion criteria

Exclusion criteria: 1. Substance misuse or dependence (other than alcohol) 2. Major psychiatric morbidity such as psychosis 3. Clinically significant abnormality on physical examination or investigation 4. Pregnancy or breast feeding 5. Taking acamprosate, disulfiram or naltrexone

Design outcomes

Primary

Measure	Time frame
Spielberger State and Trait Anxiety Inventory, Beck Depression Inventory, OCDS. Alcohol Urge Questionnaire, and visual analogue scores to rate craving and mood.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026