Effect of high-fat, high-carbohydrate meals in human

Antioxidant enzymes induced by repeated intake of high-fat, high-carbohydrate meals are not sufficient to block oxidative stress in healthy lean subjects: A randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN04309078

Enrollment

Registered

2010-08-05

Start date

2010-05-06

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diet

Interventions

Ten healthy, lean male Korean subjects were enrolled in this study. Subjects started a standardized diet for 7 days with control meals for breakfast, lunch and dinner, based on the Dietary Reference I

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers 2. Age 28 - 32 years 3. Male 4. Body Mass Index (BMI): 18.5 - 22.9

Exclusion criteria

Exclusion criteria: 1. Complete Blood Count (CBC): white blood cells - more than 6,000/ul 2. Fasting blood sugar test: blood sugar concentration - more than 100 mg/dl 3. Haemoglobin A1c: more than 6.0%

Design outcomes

Primary

Measure	Time frame
1. Oxidative stress 2. Anti-oxidant enzyme expressions 3. Mitochondria transport chain complex subunits expressions	—

Secondary

Measure	Time frame
Insulin resistance	—

Countries

Korea, South

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026