Absorption of orange juice polyphenols

Bioavailabilty of Orange Juice polyphenols: a cross-over, non-randomised intervention

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN04271658

Enrollment

Registered

2014-07-23

Start date

2012-01-03

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bioavailabilty of orange juice polyphenols Not Applicable

Interventions

Each subject will drink 250 ml of pulp-enriched orange juice. A light breakfast consisting of white bread, cheese, ham and milk will be provided 2 h after orange juice intake. After a wash-out period

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy men and women. 2. Age 20-65 years

Exclusion criteria

Exclusion criteria: 1. Smoking 2. On no medication

Design outcomes

Primary

Measure	Time frame
The absolute bioavailability of orange juice phenolics will be the primary outcome of this study. Polyphenol metabolites and catabolites will be identified and quantified in urine collected over five time periods (0, 0-2, 2-5, 5-10 and 10-24 hours) following supplementation, using high-performance liquid chromatography coupled with tandem mass spectrometry and gas chromatography coupled with mass spectrometry.	—

Measure

Time frame

The absolute bioavailability of orange juice phenolics will be the primary outcome of this study. Polyphenol metabolites and catabolites will be identified and quantified in urine collected over five time periods (0, 0-2, 2-5, 5-10 and 10-24 hours) following supplementation, using high-performance liquid chromatography coupled with tandem mass spectrometry and gas chromatography coupled with mass spectrometry.

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 19, 2026