Delayed brain radiation injury/temporal lobe necrosis/oncology Cancer Radiation
Conditions
Interventions
In the AMT active treatment group, all former treatments with corticosteroids were discontinued for patients prior to AMT initiation. Our initial treatment protocols (Treatment First Phase) comprised
Sponsors
Sun Yat-sen University (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who fulfilled the following eligibility criteria were recruited in this study: 1. Aged 18 to 65 years 2. Histopathologically proven cases of NPC who had undergone radiation therapy, with negative brain MR before RT 3. Patients must have received cranial irradiation = 6 months prior to study entry 4. MRI evidence of bilateral temporal lobe edema and/or necrosis with or without foci of contrast enhancement on MRI 5. Evidence of progressive neurologic signs or symptoms related with TLN
Exclusion criteria
Exclusion criteria: Patients were excluded if they had: 1. Significant hepatic or renal insufficiency 2. Evidence of brain metastasis, brain abscess, any intracranial tumor, cerebral infarction, demyelinating disease 3. Clinical manifestations such as fever, meningeal irritatation signs indicating meningitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Activities of daily living (ADL) were adopted to assess subjects? neurological status. ADL were assessed by the Barthel Index (BI) (0?100 scale, with lower scores denoting less independence in activities of daily living) | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation by MRI tests | — |
Countries
China
Outcome results
None listed