The effect of reducing heart rate on central aortic blood pressure: a comparative study of ivabradine and atenolol on haemodynamic parameters at rest

Ethics approval was received from the local Cambridge medical ethics committee before trial recruitment began.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN03804536

Enrollment

Registered

2007-09-28

Start date

2006-06-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular: Haemodynamic parameters at rest Circulatory System Haemodynamic parameters at rest

Interventions

STUDY DESCRIPTION Up to 24 healthy people will be recruited in to the study via a poster asking for volunteers. The study will consist of 4 visits. 14/09/2012: Please note that this trial was stopped

Eligibility

Inclusion criteria

Inclusion criteria: 1. Volunteers aged 18-65 2. Subjects able to give informed consent 3. Normal blood pressure (< 140/90 mmHg but = 110/70 mmHg) 4. Resting heart rate = 50 beats per minute

Exclusion criteria

Exclusion criteria: 1. Subjects with a history of hypertension or diabetes mellitus 2. Volunteers with a conduction defect on the ECG 3. Resting heart rate < 50 beats per minute and blood pressure < 110/70 mmHg 4. Pregnant women or those of childbearing age taking inadequate contraception 5. Volunteers with a history of asthma, cardiovascular disease or arrhythmias 6. Participants with a history of intolerance to beta-blockers or ivabradine

Design outcomes

Primary

Measure	Time frame
Assessing change in central blood pressure	—

Secondary

Measure	Time frame
Assessing change in haemodynamic parameters	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026