MCA stroke (acute ischaemic or intracerebral haemorrhage (ICH) Circulatory System Intracerebral haemorrhage
Conditions
Interventions
All participants will receive standard care, and in addition to this, two (60 minutes) weekly sessions of active music therapy in individual setting over a period of 3 months. Standard care follows th
Sponsors
University of Jyvaskyla (Finland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Current information as of 03/11/09: 1. Middle cerebral artery ( MCA) stroke (an acute ischaemic stroke or ICH) in the right temporal, parietal frontal and/or subcortical brain region 2. No prior clinically diagnosed cerebral stroke, but old ischemic or stroke changes may be detected as an incidental finding in the brain MRI. 3. No prior significant neurological or psychiatric disease excluding vascular aetiology (e.g. transient ischaemic attack [TIA]), migraine, epilepsy, non-symptomatic tumour or mild depression 4. Under 21 days post-stroke 5. No hearing impairment 6. No significant visual impairment 7. Aged less than or equal to 75 years old, either sex 8. Right-handed 9. Native Finnish speaker 10. Understands the aim of the study and is able to give own consent Initial information at time of registration 1. An acute ischaemic middle cerebral artery (MCA) stroke in the right temporal, parietal frontal and/or subcortical brain region 2. No prior cerebral stroke 3. No prior significant neurological or psychiatric disease excluding vascular aetiology (e.g. transient ischaemic attack [TIA]), migraine, epilepsy, non-symptomatic tumour or mild depression 4. Under 21 days post-stroke 5. No hearing impairment 6. No significant visual impairment 7. Aged less than or equal to 75 years old, either sex 8. Right-handed 9. Native Finnish speaker 10. Understands the aim of the study and is able to give own consent
Exclusion criteria
Exclusion criteria: 1. Stroke (an acute ischaemic stroke or ICH) in any other region than right-hemisphere MCA 2. Prior cerebral stroke 3. Prior neurological and or psychiatric disease, which significantly affects patient functioning 4. Over 21 days post-stroke 5. Hearing impairment 6. Significant visual impairment 7. Aged greater than 75 years old 8. Left-handed 9. Native language other than Finnish 10. Patient displays cognitive disorders and is, in turn, unable to understand the aim of the study or to give own consent to participate in this study 11. Patient is bedridden or has a modified Rankin scale score =4
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured in four phases: before randomisation, and after three, four (washout) and seven months after stroke. Magnetic resonance imaging (MRI) will be used for ensuring the diagnosis before initial tests. 1. Functional disability and activities of daily living (ADL) independency will be measured with the Barthel Index (BI) 2. Level of impairment will be evaluated with National institutes of Health Stroke Scale (NIHSS) 3. Disability grade will be assessed with Modified Rankin Scale (mRS) 4. Neglect will be evaluated with Behavioural Inattention Test (BIT) 5. Motor function of upper extremity will be assessed with Action Research Arm Test (ARAT) | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured in four phases: before randomisation, and after three, four (washout) and seven months after stroke. Magnetic resonance imaging (MRI) will be used for ensuring the diagnosis before initial tests. 1. An extensive test battery of neuropsychological tests will cover the following areas: verbal and visual memory functions, working memory, visual perception, attention, executive functions and basic verbal functions. In addition, the neuropsychological assessment includes finger tapping, mood, quality of life, and self-awareness questionnaires. 2. Continuous and selective attention will be studied with Go/No-Go event-related potential (ERP) procedure. In addition, the electroencephalogram (EEG) recordings will include rest, musical stimulus, and mismatch negativity parts for studying auditory perception and activations of brain areas. 3. Motor function will be assessed with the help of following tests: box and block for measuring unilateral gross manual dexterity, pinch meter for measuring pinch force, jamar-meter for measuring grip force, and postural control and balance by sitting with Postural Control and Balance for Stroke (PCBS) test 4. Changes in motor function and skills (e.g. overall amount of movement, the range of movement and accuracy in motion) will be measured with Motion capture (MoCap) recording 5. Music analysis will be conducted by using special computational methods: Music Therapy Toolbox (MTTB) and Music Information Retrieval (MIR) for extracting particular musical features. Analysis is focused on musical interaction between patient and therapist, and to examine if clinical change is mediated by observable and measurable changes in music (such as synchronisation, clarity of pulse etc.). Musical data and special features will be used for complementing the data from MoCap (e.g. velocity on studying the accuracy in motion). 6. Every therapy session will be video-recorded, and the data will be used for studying the individual therapy processes, and | — |
Countries
Finland
Outcome results
None listed