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Diabetes Remission Clinical Trial

Reversal of type 2 diabetes mellitus (T2DM) using non-surgical weight management with Low-Energy-Liquid-Diet and long-term maintenance, within routine NHS care

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN03267836
Enrollment
280
Registered
2013-12-20
Start date
2014-01-01
Completion date
Unknown
Last updated
2024-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes Nutritional, Metabolic, Endocrine Type 2 diabetes mellitus

Interventions

Practices randomised to the intervention will deliver Counterweight Plus, which includes a Total Diet Replacement phase followed by structured food reintroduction and long-term weight loss maintenance

Sponsors

NHS Greater Glasgow and Clyde (UK)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Men and women aged 20-65 years, all ethnicities 2. T2DM of duration 0-6 years 3. Body Mass Index (BMI) >27 kg/m2

Exclusion criteria

Exclusion criteria: 1. Current insulin use 2. HbA1c =12% 3. Substance abuse 4. Known cancer 5. Myocardial infarction within previous 6 months 6. Learning difficulties 7. Current treatment with anti-obesity drugs 8. Diagnosed eating disorder or purging 9. Pregnant/considering pregnancy 10. Patients who have required hospitalisation for depression or are on antipsychotic drugs

Design outcomes

Primary

MeasureTime frame
Reduction in weight of 15 kg (assumed equal on average to 15%) or more Co-primary outcome: Reversal of diabetes (HbA1c <6.5%) Both outcomes measured at 1 year

Secondary

MeasureTime frame
1. Quality of life measured by EQ-5D questionnaire 2. Physical activity level measured using Sensewear Monitor 3. Serum lipids All outcomes measured at 1 year

Countries

Scotland, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 14, 2026