Endoscopic sclerotherapy compared with no specific treatment for the primary prevention of bleeding from oesophageal varices: a randomised controlled multicentre trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN03215899

Enrollment

166

Registered

2003-08-13

Start date

1986-05-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver cirrhosis Digestive System Liver cirrhosis

Interventions

Prophylactic sclerotherapy versus no specific treatment. For more information, please contact the College voor Zorgverzekeringen (Health Care Insurance Board) on infoSBA@cvz.nl.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adults with endoscopically documented grade II, III or IV oesophageal varices 2. Absence of prior bleeding from varices 3. Evidence of active and/or progressive liver disease (e.g. as indicated by repeatedly elevated serum transaminases or increasing serum bilirubin levels or development of ascites within the past year) 4. Documented increase in the size of oesophageal varices 5. All patients gave informed consent

Exclusion criteria

Exclusion criteria: 1. Use of beta-blockers and nitrates 2. Malignancy 3. Haemophilia 4. Age older than 70 - 75 years 5. No opportunity for follow-up visits

Design outcomes

Primary

Measure	Time frame
Not provided at time of registration	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

Netherlands

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026