A comparison of high cocoa solid with absent cocoa solid chocolate in patients with chronic fatigue syndrome in a double blind randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN03090939

Enrollment

Registered

2007-01-26

Start date

2005-10-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic fatigue syndrome Nervous System Diseases Fatigue

Interventions

Double blind cross over study using chocolate containing high polyphenols with low polyphenol chocolate with two weeks washout, eight weeks of initial intervention and eight weeks of cross-over interv

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age group 18 to 35 2. Diagnosis of CFS as defined by the Centers for Disease Control (CDC) criteria 3. Severity of fatigue - a score of at least ten (out of 11) on the Chalder-Fatigue Scale (binary scored)

Exclusion criteria

Exclusion criteria: 1. Benzodiazepine use in the previous two months 2. Unwillilng to give written, informed consent 3. Unable to complete study questionnaires

Design outcomes

Primary

Measure	Time frame
Improvement of fatigue using Chandler Fatigue scale, London Handicap Scale and Hospital Anxiety and Depression Scale.	—

Secondary

Measure	Time frame
Change in weight	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026