Osteoarthritis/avascular necrosis Musculoskeletal Diseases Polyarthrosis
Conditions
Interventions
Total knee replacement surgery versus unicompartmental knee replacement surgery. Patients will be followed up for 10 years post surgery. Going on the average waiting list times of 3 months, the approx
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Medial osteoarthritis with exposed bone on both femur and tibia or avascular necrosis 2. Functionally intact anterior cruciate ligament (superficial damage or splitting is acceptable) 3. Full thickness lateral cartilage 4. Correctable intra-articular varus deformity (suggestive of functionally intact medical cruciate ligament) 5. Medically fit showing an American Society of Anaesthesiologists (ASA) grade 1 or 2 6. Expectancy of over 10 years of active life 7. Aged 40 years or over, either sex
Exclusion criteria
Exclusion criteria: 1. Require revision knee replacement surgery 2. Have rheumatoid arthritis or other inflammatory disorders 3. Are likely to benefit from a specific prosthesis type 4. Are unlikely to be able to perform required clinical assessment tasks 5. Have symptomatic foot, hip or spinal pathology
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxford Knee Score: a patient based validated and effective measure of change over time questionnaire. Both the absolute and the change scores will be analysed at 5- and 10-year points post-operation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. American Knee Society Score: to measure the range of motion and function of the knee, measured at 2 months, 1, 5 and 10 years post-surgery 2. UCLA Activity Score: to measure how active the patient is, measured at 2 months, 1, 5 and 10 years post-surgery 3. X-ray to check for immediate problems, assess the outcome of surgery, complications and make long-term predictions, measured at 2 months, 1, 5 and 10 years post-surgery 4. EQ-5D: to provide data for the economic evaluation, measured at 2 months, 1, 2, 3, 4, 5, 7 and 10 years post-surgery 5. Lund Score: to measure patient satisfaction, measured at 2 months, 1, 2, 3, 4, 5, 7 and 10 years post-surgery 6. Other outcomes, e.g., kinematic and gait assessments, measured at 2 months, 1, 5 and 10 years post-surgery | — |
Countries
England, Northern Ireland, Scotland, United Kingdom, Wales
Outcome results
None listed