Effects of increased consumption of leaf and stalk vegetables and beetroot on cardiovascular function: VegBP project

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN03012467

Enrollment

225

Registered

2010-10-27

Start date

2010-07-15

Completion date

Unknown

Last updated

2017-10-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Primary Care Research Network for England, Cardiovascular, Generic Health Relevance and Cross Cutting Themes

Interventions

Vegetable Group 1: Additional consumption of 100 g per day of vegetables from mixed leaf lettuce, beetroot and spinach for a 16-week intervention period Vegetable Group 2: Additional consumption of 10

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male or female subjects aged 40 - 75 years 2. Systolic blood pressure in the range 130 - 150 mmHg

Exclusion criteria

Exclusion criteria: 1. Body mass index (BMI) greater than 30 kg/m2 2. Habitual consumption of green leafy vegetables higher than the population mean (= exclusion of the highest quartile, since the distribution of intake is highly skewed) 3. Recent or current serious disease (cancer, cardiovascular disease [CVD], etc.) 4. History of persistent gastric reflux or H. pylori infection 5. Allergies or intolerances to intervention foods 6. Planning to change dietary habits, increase physical activity, change body weight or move away from the study locality during the time of the study 7. Smokers 8. Taking antihypertensives for elevated blood pressure 9. Taking prescribed nitrates for angina or heart failure 10. Taking statins 11. History of substance abuse or alcoholism

Design outcomes

Primary

Measure	Time frame
Seated Blood Pressure, measured twice within 1 week every 8 weeks over a 24 week period (8 times in total).	—

Secondary

Measure	Time frame
1. 24-hour ambulatory blood pressure, measured once every 8 weeks over a 24-week period (4 measurements in total) 2. C-reactive protein (CRP) and biochemical markers of endothelial function, measured twice within 1 week every 8 weeks over a 24-week period (8 times in total) 3. Fasting blood glucose, measured once every 8 weeks over a 24-week period (4 measurements in total) 4. Fasting blood lipid profile, measured twice within 1 week every 8 weeks over a 24-week period (8 measurements in total) 5. Flow mediated dilation, measured once every 8 weeks over a 24-week period (4 measurements in total) 6. Plasma carotenoids and polyphenols, measured twice within 1 week every 8 weeks over a 24-week period (8 times in total) 7. Weight and body composition, measured once every 8 weeks over a 24-week period (4 times in total)	—

Measure

Time frame

1. 24-hour ambulatory blood pressure, measured once every 8 weeks over a 24-week period (4 measurements in total) 2. C-reactive protein (CRP) and biochemical markers of endothelial function, measured twice within 1 week every 8 weeks over a 24-week period (8 times in total) 3. Fasting blood glucose, measured once every 8 weeks over a 24-week period (4 measurements in total) 4. Fasting blood lipid profile, measured twice within 1 week every 8 weeks over a 24-week period (8 measurements in total) 5. Flow mediated dilation, measured once every 8 weeks over a 24-week period (4 measurements in total) 6. Plasma carotenoids and polyphenols, measured twice within 1 week every 8 weeks over a 24-week period (8 times in total) 7. Weight and body composition, measured once every 8 weeks over a 24-week period (4 times in total)

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026