Acute self-poisoning in the developing world Injury, Occupational Diseases, Poisoning Self-poisoning
Conditions
Interventions
No charcoal, single 50 g dose of superactivated charcoal, multiple doses (6 x every four hour doses of superactivated charcoal).
The anticipated end date of this trial has been extended to the 1st De
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All patients presenting with a history of acute self-poisoning in selected Sri Lankan hospitals
Exclusion criteria
Exclusion criteria: We hope to recruit all patients admitted to the medical wards with a history of acute poisoning, except for those: 1. Under the age of 14 years 2. Known to be pregnant 3. Who have ingested hydrocarbons alone or corrosives (good prognosis for former, charcoal contraindicated for latter) 4. Who require oral medication 5. Who present more than 72 hours post-ingestion 6. Patients under the age of 16 or unconscious, who are present without relatives
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality at hospital discharge. | — |
Secondary
| Measure | Time frame |
|---|---|
| Organophosphate pesticides: 1. Percentage of patients requiring intubation 2. Period of ventilation 3. Percentage of patients developing the intermediate syndrome (cranial nerve palsies and/or proximal weakness, without distal weakness, after resolution of the cholinergic crisis) Organochlorine pesticides: Incidence of status epilepticus (continuous overt generalised seizure activity for mroe than five minutes or two generalised seizures without an intervening recovery of consciousness) Yellow oleander: 1. Cardiac dysrhythmias requiring anti-digoxin Fab (3° heart block, Mobitz type II 2° block, sinus bradycardia with heart rate less than 35 bpm, and sinus arrest or block with sinus pauses more than 3 seconds), or 2. Serum potassium greater than 6.0 | — |
Countries
Sri Lanka
Outcome results
None listed