Topic: Primary Care Research Network for England
Conditions
Interventions
21 men with T2D will perform two 8-week exercise interventions in a counterbalanced crossover design, separated by =6 weeks. Before and three days after each 6-week intervention all participants will
Sponsors
University of Bath (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Men aged =40 years and =60 years 2. Diagnosed with Type 2 diabetes according to WHO criteria at least 6 months prior to entering the study: fasting plasma glucose = 7.0 mmol/l (126 mg/dl) - OR 2-hour plasma glucose sample in a standard OGTT of =11.1 mmol/l (200 mg/dl)
Exclusion criteria
Exclusion criteria: 1. Insulin therapy 2. Use of sulphonylureas 3. Use of more than two anti-diabetic drugs 4. Use of ß-blockers 5. Use of inhaled steroids (e.g., for asthma) 6. Any cardiovascular condition with the exception of well-controlled uncomplicated hypertension treated with no more than two drugs (either an ACE, ARB, calcium channel blocker or diuretic) 7. Cerebrovascular disease including previous stroke or aneurysm 8. History of exercise-induced asthma 9. History of Type 1 diabetes mellitus or a history of ketoacidosis 10. History of other specific types of diabetes (e.g., genetic syndromes, secondary pancreatic diabetes, diabetes due to endocrinopathies, drug- or chemical-induced, and post-organ transplant) 11. Any prior history of malignancy with the exception of: 11.1. Basal cell carcinoma of the skin 11.2. Squamous cell carcinoma of the skin that has been recurrence-free for 5 years 11.3. Other malignancies (regardless of site) that have been recurrence-free for 5-10 years 12. BMI >35 kg/m2 13. Uncontrolled hypertension (systolic blood pressure >160 mmHg and/or diastolic blood pressure >90 mmHg after at least a 5-minute seated rest at the screening visit) 14. A clinically significant ECG abnormality at the screening visit which in the opinion of the investigators exposes the subject to risk by enrolling in the trial 15. Overt contraindications to exercise as determined with a normal resting ECG 16. ?Yes? to any questions on a standard physical activity readiness questionnaire (PAR-Q) 17. Classification as highly physically active on the International Physical Activity Questionnaire (IPAQ) 18. Current participation in another research study 19. Inability to fully understand the verbal and written descriptions of the study in English, and the instructions provided during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycaemic control; timepoint(s): pre and post both interventions | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Aerobic fitness; timepoint(s): pre and post both interventions 2. Body composition; timepoint(s): pre and post both interventions | — |
Countries
United Kingdom
Outcome results
None listed