Copeptin, Pro-Atrial Natriuretic Peptide (Pro-ANP) and Pro-Adrenomedullin (Pro-ADM) as markers of hypoxic stress in patients with obstructive sleep apnoea syndrome (OSAS)

Copeptin, Pro-Atrial Natriuretic Peptide (Pro-ANP) and Pro-Adrenomedullin (Pro-ADM) as markers of hypoxic stress in patients with obstructive sleep apnoea syndrome (OSAS): a prospective intervention trial

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN02302064

Enrollment

300

Registered

2010-10-28

Start date

2010-09-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive sleep apnoea syndrome (OSAS) Respiratory Sleep disorders

Interventions

Visit 1a: informed consent, medical history, current medical status, demographics, vital signs, height and body weight, epworth sleepiness score, SF-36, overnight pulsoxymetry Visit 1b: venous punctur

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 or older 2. Patients with suspicion of obstructive sleep apnoea syndrome or central apnoea events

Exclusion criteria

Exclusion criteria: 1. Mental disorder preventing appropriate judgment concerning study participation 2. Significant co morbidity resulting in reduced life expectancy (lower than 6 months) 3. Planned emigration or relocation within the country during the study period 4. Pregnancy and breast-feeding

Design outcomes

Secondary

Measure	Time frame
1. Median circulating copeptin, Pro-ANP and Pro-ADM levels before treatment and after 1 and 6 months of treatment respectively 2. Change in median circulating copeptin, Pro-ANP and Pro-ADM levels after 1 night and 6 months of CPAP treatment respectively In a second step, endpoints will be assessed in subgroups of patients according to OSAS severity	—

Primary

Measure	Time frame
Change in median circulating copeptin, Pro-ANP and Pro-ADM levels after 1 month of CPAP or BiPAP treatment	—

Countries

Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026