Intensified HIV/TB prevention linking home-based HIV testing, including the option of self-testing, with HIV care

Conditions

Human immunodeficiency virus (HIV)/Tuberculosis (TB) Infections and Infestations Human immunodeficiency virus (HIV) disease/Tuberculosis

Hendramoorthy Maheswaran, Aileen Clarke, Peter MacPherson, Felistas Kumwenda, David G. Lalloo et al. (7 authors)

Clinical Infectious Diseases2017-11-0838 citations

10.1093/cid/cix983

Economic Costs and Health-Related Quality of Life Outcomes of HIV Treatment After Self- and Facility-Based HIV Testing in a Cluster Randomized Trial.

Maheswaran H, Petrou S, MacPherson P, Kumwenda F, Lalloo DG, Corbett EL, Clarke A.

2017-07-0110 citations

10.1097/qai.0000000000001373

Cost and quality of life analysis of HIV self-testing and facility-based HIV testing and counselling in Blantyre, Malawi.

Maheswaran H, Petrou S, MacPherson P, Choko AT, Kumwenda F, Lalloo DG, Clarke A, Corbett EL.

2016-02-1981 citations

10.1186/s12916-016-0577-7

Interventions

Intervention versus Standard of Care (SOC) Intervention: 1. Provision of access to home-based HIV testing and counselling and tuberculosis (TB) symptom screening, incl

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Home-based HIV testing and counselling: 1. Age 16 years or above 2. Usual residence within a study cluster 3. Able and willing to provide written or witnessed informed consent to HTC, either as standard counsellor-provided or as supervised self-testing Supervised self-testing only: 1. Attends in person to collect kit 2. Passes a test of understanding 3. Agrees to return test kit packaging and the used kit in a sealed envelope 4. Agrees to receive post-test health information

Exclusion criteria

Exclusion criteria: 1. Age 15 years or below 2. Usual residence outside of the intervention cluster 3. Has tested previously on 2 occasions under the community counsellor system

Design outcomes

Primary

Measure	Time frame
The case-notification rate of bacteriologically-confirmed TB in adult (16 yrs or older) cluster residents, in months 7 to 31 of intervention	—

Secondary

Measure	Time frame
1. The case-notification rate of bacteriologically-confirmed TB in HIV-positive adult residents in months 7 to 31 of intervention. This analysis will use cluster-specific HIV prevalence estimate from a post-intervention HIV/TB prevalence survey as the denominator 2. The prevalence of HIV infection that, by self-report, is either undiagnosed (no previous positive HIV test) or not being treated [neither antiretroviral therapy (ART), nor cotrimoxazole nor isoniazid preventive therapy (IPT)] at the time of the post-intervention prevalence survey (month 31 after the start of intervention)	—

Measure

Time frame

1. The case-notification rate of bacteriologically-confirmed TB in HIV-positive adult residents in months 7 to 31 of intervention. This analysis will use cluster-specific HIV prevalence estimate from a post-intervention HIV/TB prevalence survey as the denominator 2. The prevalence of HIV infection that, by self-report, is either undiagnosed (no previous positive HIV test) or not being treated [neither antiretroviral therapy (ART), nor cotrimoxazole nor isoniazid preventive therapy (IPT)] at the time of the post-intervention prevalence survey (month 31 after the start of intervention)

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Countries

Malawi

Outcome results

None listed