Topic: Neurological, Generic Health Relevance and Cross Cutting Themes
Conditions
Interventions
Working memory training: 5-weeks of computerised working memory training (approximately 30-mins per day for 5 days per week)
Study Entry: Single Randomisation only
Sponsors
University of East Anglia (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Current inclusion criteria as of 20/02/2018: Participant inclusion criteria Potential participants for intervention and placebo group will: 1. Male & female, aged between 8 and 16 years 2. Score at or below the 30th centile on two tasks of verbal WM, listening recall and backward digit recall, from the Automated Working Memory Assessment (AWMA, Alloway, 2007) 3. Be medically stable 4. Be computer literate, and will have access to a computer and the internet 5. Speak English Participants will have documented evidence of non-progressive ABI, defined as a moderate (Glasgow Coma Scale (GCS) 8 - 12, Post Traumatic Amnesia (PTA 1 - 24 hours) to severe (GCS 24 hours) TBI, stroke, herpes encephalitis, and infratentorial tumour with resection or cranial radiotherapy. Previous inclusion criteria: Potential participants for intervention and placebo group will: 1. Male & female, aged between 8 and 16 years 2. Score at or below the 30th centile on two tasks of verbal WM, listening recall and backward digit recall, from the Automated Working Memory Assessment (AWMA, Alloway, 2007) 3. Be medically stable 4. Be computer literate, and will have access to a computer and the internet 5. Speak English For the feasibility/acceptability pilot: participants will have documented evidence of non-progressive ABI, defined as a TBI, stroke, herpes encephalitis, and infratentorial tumour with resection or cranial radiotherapy. For the full study: participants will have documented evidence of non-progressive TBI and will be survivors of moderate (Glasgow Coma Scale (GCS) 8 ? 12, Post Traumatic Amnesia (PTA 1 ? 24 hours) to severe (GCS 24 hours) brain injury.
Exclusion criteria
Exclusion criteria: Participants will be excluded if: 1. There is evidence of severe damage to organs other than the brain, major medical problems, or the presence of significant mood disturbance. 2. There is evidence of a progressive neurodegenerative condition. 3. There is a pre-morbid history of learning disability or a specific learning impairment affecting working memory (e.g., dyslexia, specific language impairment), conduct disorder, current use of medication impacting on cognition, or a lack of English proficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Working memory performance; Timepoints: immediately post-training, and at 6-months follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| Academic performance, with further exploratory measures of: executive function and attention, classroom engagement and participation, and perceived family burden and the patients quality of life | — |
Countries
United Kingdom
Outcome results
None listed