Topic: Cardiovascular
Conditions
Interventions
The stimulus for RIPC that will be used will be inflation of a blood pressure cuff placed around the upper arm. The cuff will be inflated to 200 mmHg for 5 minutes after which it will be deflated for
Sponsors
University College London (UCL) (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years 2. Patients undergoing coronary bypass surgery with or without concomitant heart valve surgeries 3. Male and female patients
Exclusion criteria
Exclusion criteria: 1. Aged under 18 years 2. Patients with severe renal impairment (estimated glomerular filtration rate less than 45 ml/min/1.73m2) 3. Patients with severe hepatic impairment 4. Patients with cardiac arrest in the previous 6 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial injury, assessed by Troponin T and creatine kinase myocardial band (CK-MB) levels over the 72 hours post-CABG surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ionotropic score, measured at first week post-operative period 2. Ventilation times, measured at the timepoint when patients are weaned from ventilator in the ITU (first 2 days post-operative period) 3. Intensive care unit (ITU) stay, measured at first week post-operative period | — |
Countries
United Kingdom
Outcome results
None listed