Skip to content

Spraying And Nets Towards malaria Elimination

Can indoor residual spraying provide additional protection against clinical malaria over current best practice of long-lasting insecticide impregnated nets? A cluster-randomised controlled trial in children in The Gambia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN01738840
Enrollment
7700
Registered
2010-10-19
Start date
2010-03-01
Completion date
Unknown
Last updated
2018-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria morbidity and infection Infections and Infestations Malaria

Interventions

1. DDT indoor residual spraying: with rooms sprayed with DDT (2 g/m2), in May/June, at the start of the main malaria transmission season, in 2010 and 2011. 2. Long-lasting insecticidal nets (LLINs):

Sponsors

Medical Research Council Laboratories (Gambia)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. No distinctions will be made regarding gender or ethnic group 2. Children (aged 6 months - 13 years old) whose parents/carers give written, informed consent for their child 3. Eligible children greater than 6 years old will also be explained the purpose of the study and what is required according to their capability 4. In the case of school age children, only those who live in their village during term-time In order for the results from this study to be as generalisable as possible, no distinctions will be made in terms of medical condition or physical health.

Exclusion criteria

Exclusion criteria: 1. Children for whom informed consent is not or cannot be provided 2. Aged under 6 months or over 13 years on 1st June for the year of survey 3. Expected to be non-residence during several months of the transmission season

Design outcomes

Primary

MeasureTime frame
Incidence of clinical episodes of malaria presenting at health facilities defined as a child with an axillary temperature of greater than or equal to 37.5°C or a history of fever in the past 48 hours, together with the presence of P. falciparum parasites of any density detected by microscopy and/or RDT in the absence of other detectable cause of fever.

Secondary

MeasureTime frame
1. Mean haemoglobin concentration in children in the two study arms measured in the end of the transmission season survey 2. Parasite prevalence in children in the two study arms measured at the end of the transmission season

Countries

Gambia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 28, 2026