Decrease in liver failure after liver resection for any diagnosis Digestive System
Conditions
Interventions
Both randomized groups will undergo the same preoperative and intraoperative management.
The only difference in postoperative management will be use of N-acetylcysteine infusion - 150 mg/kg of NAC in
Sponsors
Alberta Health Services (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All adult patients scheduled to undergo major hepatic resection (defined as the removal of at least two Couinaud segments) for any cause at the Foothills Medical Centre who give written informed consent are eligible for the study.
Exclusion criteria
Exclusion criteria: Participation in other trials before or during treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall complication rate. These will be recorded in a prospective fashion throughout the trial. Coding will then be done according to the Clavien-Dindo classification, which is the most common description of types of complications (grade I, II, IIIa, IIIb, IVa, IVb and V). | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative liver failure as defined by: 1. The 50-50 criterion (PT>50% (INR>1.7), bilirubin > 50 umol/l (3 mg/dL) on postoperative day 5) 2. Length of stay 3. Postoperative mortality | — |
Countries
Canada
Outcome results
None listed