Postoperative pain during laparoscopic cholecystectomy Surgery Pain
Conditions
Interventions
During laparoscopic cholecystectomy depending on the randomised three groups patients will receive three doses of pregabalin 50 mg/75 mg, first dose one hour after surgery and then every twelve hours
Sponsors
Pfizer (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients 18 to 65 years of age undergoing cholecystectomy under general anesthesia 2. Able to tolerate standard medications - 1000 mg of acetaminophen and 500 mg of naproxen
Exclusion criteria
Exclusion criteria: 1. Clinically diagnosed acute pancreatitis requiring urgent cholecystectomy 2. Allergy to gabapentin or pregabalin 3. Allergy to Non-Steroidal Anti-Inflammatory Drugs (NSAID) or acetaminophen 4. No analgesic within 24 hours before surgery (other than premedication) 5. Patients with Body Mass Index (BMI) more than 40 6. Serious organ disease 7. Creatinine clearance less than or equal to 60 mL 8. Chronic pain patients requiring more than 30 mg morphine per day or equivalent 9. Severe psychiatric disease 10. Drug addiction 11. Pregnancy 12. Language barrier
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Postoperative pain score (Numerical Rating Score [NRS]) in Post Anaesthesia Care Unit (PACU), one hour, six hours, day one, day two and day seven after surgery at rest and movement 2. Time to first analgesic consumption 3. Discharge time from PACU 4. Consumption of analgesics in the postoperative period up to day seven | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. General tolerability of the regimens 2. Sleep quality 3. Quality of Recovery 40-item questionnaire (QoR-40) 4. Adverse effects including Opioid-Related Symptom Distress Scale (ORSDS) 5. Patient satisfaction | — |
Countries
Canada
Outcome results
None listed