Surgery: Abdominal aortic aneurysm (AAA) repair Surgery Abdominal aortic aneurysm
Conditions
Interventions
Patients are randomised to receive either glucose-insulin-potassium or ALK or normal saline solution.
Specimen collection in Theatre. Selly Oak Hospital Intensive Therapy Unit (ITU) and on Selly Oak H
Sponsors
Department of Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 60 patients requiring elective infra-renal aortic surgery for aneurysm disease will be recruited over 18 months in the Department of Vascular Surgery. All 60 patients will be randomised to receive the "study solution" either ALK or normal saline control. A further group of 30 patients (age and sex matched controls) undergoing elective abdominal, non vascular surgery will also be studied. They will not have any therapeutic interventions but will be managed as per usual by the medical teams looking after them. Cardiac and skeletal muscle damage and systemic inflammation will be measured in these patients for up to 5 days post operatively.
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Patients 200 gmol/I
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A reduction in cardiac Tropinin I release of 0.75 standard deviations from the mean in the GIK group compared with the control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary (in GIK group) - Reduced cardiac ischaemia as measured by electrocardiogram (ECG), creatinine kinase (CK) total and CK-MB, reduced inflammatory response as measured by IL6, CRP, gastric tonometry - reduced Intensive Therapy Unit (ITU) stay, intubation time. | — |
Countries
United Kingdom
Outcome results
None listed